New publication for CeeD and its spin-off ILONOV on Myokines in Nutrients journal

« Myokines: Crosstalk and Consequences on Liver Physiopathology »

Dumond Bourie A, Potier J-B, Pinget M, Bouzakri K.

Non-alcoholic fatty liver disease (NAFLD), mainly characterized by fat accumulation in the liver, is a chronic hepatic disease with a worldwide prevalence of 25%, and notably present in 2/3 of the diabetic patients. At it evolves, NAFLD can progress to a more severe form, the non-alcoholic steatohepatitis (NASH) and in some patients the disease evolves to cirrhosis and hepatocellular carcinoma, which can require a liver transplantation. To date, no specific treatment for this chronic hepatic disease exists.

For several years, the importance of inter-organs communication has been highlighted in the case of diabetes and its related metabolic diseases, such as NAFLD. The CeeD and ILONOV focus mainly on the beneficial effect of the myokines, molecules secreted by the muscle during physical activities, on the different insulin-sensitive organs such as the pancreas, the liver and adipose tissue.

Through this review, our teams have summarized the existing literature to put a light on the role of different myokines on the physiopathology of NAFLD, and on their beneficial effect on different hallmarks of NAFLD and its complications, such as lipid accumulation, inflammation, fibrosis for example. Thus, this review highlights the potential therapeutic role that could have myokines in the treatment of non-alcoholic hepatic diseases.

Link to the paper: https://www.mdpi.com/2072-6643/15/7/1729