New publication on DECORIN, a triceps-derived myokine, and type 2 diabetes on Acta Physiol (Oxf)

Janvier 30 2025

"DECORIN, a triceps-derived myokine, protects sorted β-cells and human islets against chronic inflammation associated with type 2 diabetes"


Langlois A, Cherfan J, Meugnier E, Rida A, Arous C, Peronet C, Hamdard H, Zarrouki B, Wehrle-Haller B, Pinget M, Craige SM, Bouzakri K


A good news to start the year:  CeeD laboratory reveals a new publication in Acta Physiologica journal 


  • In this paper, the research team shows that DECORIN, a new triceps-derived myokine, has a beneficial effect on human pancreatic islets, protecting them from cell death induced by inflammation.
  • This work demonstrates for the first time that DECORIN restores T2D-islet function and reverses the expression of T2D-associated genes.
  • Based on these datas, they propose DECORIN as a promising therapeutic target for diabetes-associated inflammation and diabetes itself.



Link to the paper and abstract:

https://pubmed.ncbi.nlm.nih.gov/39844653/


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