À propos de Dr BOUZAKRI Karim


Directeur du laboratoire - Directeur de l'UMR DIATHEC EA 7294


Avant de rejoindre le CeeD début 2016, Karim Bouzakri a travaillé, en autres, au Centre Médical Universitaire de Genève et au Karolinska Institutet à Stockholm.

◼ Top 10 des chercheurs dans l’insulinorésistance et le diabète de type 2 ;
◼ Pionnier dans l’étude des relations muscle-pancréas ;
◼ Lauréat du prestigieux prix « Etoile montante » de l’EASD (European Association for the Study of Diabetes) ;
◼ Titulaire d’une HDR (Habilitation à Diriger des Recherches).

Aujourd’hui directeur du laboratoire et directeur de l’UMR EA DIATHEC 7294, également en charge de la valorisation de la recherche à l’international, il mène des travaux de recherche sur la communication croisée entre les muscles squelettiques et le pancréas.

Documents à télécharger

Curriculum Vitae

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Publications list

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Principales publications

Impact of moderate dietary protein restriction on glucose homeostasis in a model of oestrogen deficiency

Crosstalk Communications Between Islets Cells and Insulin Target Tissue: The Hidden Face of Iceberg

Impact of moderate exercise on fatty acid oxidation in pancreatic β-cells and skeletal muscle

Profiling of ob/ob mice skeletal muscle exosome-like vesicles demonstrates combined action of miRNAs, proteins and lipids to modulate lipid homeostasis in recipient cells

Exercise-evoked intramuscular neutrophil-endothelial interactions support muscle performance and GLUT4 translocation: a mouse gnawing model study

Glycaemic control in diabetic rats treated with islet transplantation using plasma combined with hydroxypropylmethyl cellulose hydrogel

Beta-Cell-Specific Expression of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 5 Aggravates High-Fat Diet-Induced Impairment of Islet Insulin Secretion in Mice

Integrin and autocrine IGF2-pathways control fasting insulin secretion in β-cells

Integrin and autocrine IGF2 pathways control fasting insulin secretion in β-cells

Lymphocyte-Derived Exosomal MicroRNAs Promote Pancreatic β Cell Death and May Contribute to Type 1 Diabetes Development.

Intra-Omental Islet Transplantation Using h-Omental Matrix Islet filliNG (hOMING).

Insights on the Role of Putative Muscle-Derived Factors on Pancreatic Beta Cell Function

Skeletal Muscle-Released Extracellular Vesicles: State of the Art.

Beneficial effects of the novel marine oxygen carrier M101 during cold preservation of rat and human pancreas

Angiogenin and Osteoprotegerin are type II muscle specific myokines protecting pancreatic beta-cells against proinflammatory cytokines

Extra-Hepatic Islet Transplantation: Validation of the h-Omental Matrix Islet filliNG (hOMING) Technique on a Rodent Model Using an Alginate Carrier.

Glucose-dependent insulinotropic peptide (GIP) stimulates Glucagon-like peptide (GLP)-1 from human and mouse pancreatic islets partly via alpha-cell-derived IL-6.

IL-13 improves beta-cell survival and protects against IL-1beta-induced beta-cell death

Circulating follistatin is liver-derived and regulated by the glucagon-to-insulin ratio: a possible liver-to-pancreas feedback signal

Human skeletal myotubes display a cell-autonomous circadian clock implicated in basal myokine secretion

Expression, phosphorylation and function of the Rab-GTPase activating protein TBC1D1 in pancreatic beta-cells

Fractalkine (CX3CL1), a new factor protecting beta-cells against TNF-alpha

Mutation of SIRT1 in Familial Type 1 Diabetes

In vitro proliferation of adult human Beta-cells

Bimodal impact of skeletal muscle on pancreatic beta-cell function in health and disease

Bimodal effect on pancreatic beta-cells of secretory products from normal or insulin resistant human skeletal muscle

Interleukin-6 enhances insulin secretion by increasing L cell and alpha cell glucagon-like peptide-1 secretion

Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function

Free Fatty Acids Induce a Pro-inflammatory Response in Islets via the abundantly expressed Interleukin-1 Receptor I

siRNA-Mediated Reduction of IKKβ Prevents TNF-α-Induced Insulin Resistance in Human Skeletal Muscle

Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle

Glucose signaling via Rab-GAP AS160 in pancreatic beta-cells

IRS-1 Serine Phosphorylation and Insulin Resistance in Skeletal Muscle from Pancreas Transplant Recipients

AMPK involvement in IL6 associated enhanced glucose and fat metabolism in primary human skeletal muscle cell

Specific cleavage of insulin-like growth factor-binding protein-1 by a novel protease activity

TNF-alpha induces insulin resistance in vivo in human skeletal muscle via inhibition of AS160 phosphorylation

Effect of serum replace with Plysate on cell growth and metabolism in primary cultures of human skeletal muscle

Molecular mechanisms of skeletal muscle insulin resistance in Type 2 diabetes

IL-4 and IL-13 up-regulate intestinal trefoil factor (TFF3) expression: requirement of STAT6 and de novo protein synthesis

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate -1 in primary culture of skeletal muscle cells from Type 2 Diabetic patients

SOCS (Suppressor Of Cytokine Signalling)-3 expression and insulin resistance in skeletal muscle of obese and type 2 diabetic patients