À propos de LANGLOIS Allan

Présentation

Allan Langlois est chef de projet et responsable éthique au sein du CeeD.

Depuis sa thèse et son obtention en 2008 au CeeD, le travail de recherche d’Allan Langlois se concentre sur l’amélioration de la survie des îlots pancréatiques post-transplantation, en ciblant deux problématiques majeures au succès de la greffe : la revascularisation tardive des îlots et les réactions inflammatoires médiées par le sang (IBMIR). Ainsi, sur le modèle du Rat, il cherche à préciser les mécanismes angiogéniques et pro-inflammatoires mis en jeux pré et post implantation afin de développer des stratégies d’optimisation de la revascularisation des îlots et de limitation des réactions inflammatoires.

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Principales publications

Gastrointestinal Hormones Manipulation to Counteract Metabolic Syndrome Using Duodenal Targeted Embolization.

Oral insulin delivery, the challenge to increase insulin bioavailability: influence of surface charge in nanoparticle system

Improvement of islet graft function using liraglutide: anti-inflammatory properties

Impact of the route of insulin administration on metabolism in a diabetic rat model

Impact of an autologous oxygenating matrix culture system on rat islet transplantation outcome.

Design, characterisation, and bioefficiency of insulin-chitosan nanoparticles after stabilisation by freeze-drying or cross-linking.

Impact of pancreatic rat islet density on cell survival during hypoxia.

In vitro and in vivo investigation of the angiogenic effects of liraglutide during islet transplantation

Pro-inflammatory and pro-oxidant status of pancreatic islet in vitro is controlled by TLR-4 and HO-1 pathways.

Perfluorocarbon emulsions prevent hypoxia of pancreatic β-cells.

Improvement of rat islet viability during transplantation: validation of pharmacological approach to induce VEGF overexpression.

Instant blood-mediated inflammatory reaction during islet transplantation: the role of Toll-like receptors signaling pathways.

Role of islet culture on angiogenic and inflammatory mechanisms.

Adenoviral infection or deferoxamine? Two approaches to overexpress VEGF in beta-cell lines.

Extracellular matrix proteins involved in pseudoislets formation.

Overexpression of vascular endothelial growth factor in vitro using deferoxamine: a new drug to increase islet vascularization during transplantation.

Perfluorocarbons: new tool for islets preservation in vitro.

Influence of rapamycin on rat macrophage viability and chemotaxis toward allogenic pancreatic islet supernates.