Collaboration with the Karolinska Institutet, 2024

In the framework of her thesis follow-up committee. Daphné Bernard, PhD student at CeeD, was invited in the lab of Pr. Mikael Rydén, the Lipid laboratory at the Karolinska Institutet to optimize adipocyte isolation and culture from human biopsy. 

Adipose tissue is considered as the main tissue of lipid storage, allowing the release of fuel when organism need it (Fasting period, exercise). In a context of an excess of free fatty acid and glucose uptake, this tissue can be damaged leading to insulin resistance and finally to type 2 diabetes. Most specifically in this project, this in vitro adipocyte model will be integrated in a clinical study to evaluate the role of physical exercise in the crosstalk between adipose tissue and pancreas in a context of diabetes. In fact, exercise now represents one of the main recommendations for patients living with type 2 diabetes and adipose tissue secretion seems to be involved in the mechanisms underlying exercise benefits.